STUDY OF THE LEVEL OF TOTAL IMMUNOGLOBULIN E (IGE) IN MYCOTIC SKIN DISEASES
Artizana DUSHI, Dance VASILEVA, Sotirija DUVLIS
Abstract
This dermatological study aims to analyze fungal skin diseases caused by dermatophytes. There is a large body of scientific data that scientifically indicates that dermatophytes represent a significant public health concern worldwide. Although the clinical manifestations of these infections are well documented, the mechanisms of the immune response, especially the role of total immunoglobulin E (IgE), are not fully understood.This conceptual study scientifically analyzes the immune profile of 60 patients with dermatomycosis, focusing on the level of total IgE as an indicator of systemic sensitization. The results demonstrate a strong correlation between male gender and high IgE levels (p < 0.001), confirming at the same time that the immune response is independent of the magnitude of the clinical change. Our conclusions will ultimately show the need for a personalized therapeutic approach based on the gender and immune profile of the patient. Before examining the role and importance of IgE in dermatomycoses, we will first scientifically analyze a brief scientific and theoretical overview of dermatomycoses.Dermatophytosis is a superficial fungal infection of the skin, hair and nails caused by dermatophytes, yeasts or molds. Dermatophytosis is a prototype of mycotic infections of the skin and its adnexa, but also includes non-dermatophyte infections (P. versicolor), as well as candidiasis. These species colonize the skin, specifically the stratum corneum, on which they feed and create their habitat. The most invasive genera for humans are Trichophyton, Microsporum and Epidermophyton. Of all of them, Trichophyton rubrum stands out as the most common cause of dermatophytosis.
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